ChemInform Abstract: Synthesis of 1,2-Dihydropyrrolo[1,2-c]pyrimidin-1-ones.
β Scribed by Mercedes Alvarez; David Fernandez; John A. Joule
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
New Pyrrolo(1,2-c)pyrimidine Derivatives. -A facile method for the preparation of the title compounds (III) (31 examples) by reaction of 4-phenylpyrimidinium salts (I) with active acetylenic compounds (II) in the presence of an oxirane as acceptor for the formed HBr is given. -
## Abstract A growing body of evidence supports that pyrimidine derivatives, in which the sugar residues have been replaced by acyclic side chains, might be developed as promising anticancer agents that interfere with tumor cell proliferation, survival, and metastatic formation. In this work, we pr