ChemInform Abstract: Synthesis of 1-Oxacephams via Improved Cyclization of N-Substituted-4-formyloxyazetidin-2-ones.

✍ Scribed by Z. KALUZA

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 29 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199908263

✦ Synopsis

Synthesis of 1-Oxacephams via Improved Cyclization of N-Substituted-4-formyloxyazetidin-2-ones.

-A simple and efficient procedure for the synthesis of the 1-oxacepham skeleton from N-substituted-4-formyloxyazetidin-2-ones, readily prepared from 4-vinyloxyazetidin-2-one, is developed based on a study of the influence of protection groups and Lewis-acid catalysts on the ring closure reaction. -(KALUZA, Z.;