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ChemInform Abstract: Synthesis, Conformational Analysis and Biological Evaluation of 2-(5- Deoxy-β-D-ribofuranosyl)pyridine-4-carboxamide.

✍ Scribed by P. E. JOOS; A. DE GROOT; E. L. ESMANS; F. C. ALDERWEIRELDT; A. DE BRUYN; J. BALZARINI; E. DE CLERCQ

Book ID
112030948
Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis and Biological Evaluation of 2
Synthesis and Biological Evaluation of 2-(2-Deoxy-β-D-ribofuranosyl)pyridine-4-carboxamide
✍ Pieter E. Joos; Eddy L. Esmans; Roger A. Dommisse; André De Bruyn; Jan M. Balzar 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 German ⚖ 549 KB

## Abstract A new protected 2‐deoxy‐D‐ribose derivative, 5‐__O__‐[(__tert__‐butyl)diphenylsilyl]‐2‐deoxy‐3,4‐__O__‐ isopropylidene‐__aldehydo__‐D‐ribose (5), was synthesized starting from 2‐deoxy‐D‐ribose. This compound was coupled with 2‐lithio‐4‐(4,5‐dihydro‐4,4‐dimethyloxazol‐2‐yl)pyridine givin