ChemInform Abstract: Synthesis, Antiinflammatory and Analgesic Activity of 2-Substituted Cinchoninic Acid Isopropylamides.

✍ Scribed by A. I. MIKHALEV; M. E. KON'SHIN; A. S. ZAKS; M. V. ZUEVA; M. V. PAVLOVA; M. I. VAKHRIN

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199826180

✦ Synopsis

Synthesis, Antiinflammatory and Analgesic Activity of 2-Substituted Cinchoninic Acid Isopropylamides.

-The 2-arylamino (III) and 2-aryloxy derivatives (V), synthesized by simple substitution of chlorine in 2-chlorocinchoninic acid amide (I), are tested for their antiinflammatory and analgesic activity. While most of the compounds possess an antiinflammatory effect (most promising compound (IIIa)), analgesic activity is observed only for a few compounds (IIIa), (IIIe), (Vb), and (Vd). -(MIKHALEV, A. I.;