ChemInform Abstract: Synthesis and Theoretical Calculations of Novel 5-Aryl Substituted 2,4, 7-Trioxo- and 4,7-Dioxo-2-thioxopyrido(2,3-d)pyrimidines.
✍ Scribed by R. RODRIGUEZ; M. SUAREZ; E. OCHOA; A. MORALES; L. GONZALEZ; N. MARTIN; M. QUINTEIRO; C. SEOANE; J. L. SOTO
- Book ID
- 112035047
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The tide compounds 4a‐c have been prepared in a one‐step procedure from 2,4‐diamino‐6‐hydroxy‐pyrimidine (1) and the corresponding arylidene substituted Meldrum's acids 2a‐e in very good yields. Semiempirical theoretical calculations (AMI) reveal two favoured conformations (A and B) for
Novel 2,3-substituted-2,4-dihydro-pyrazolo[4,3-d] pyrimidine-5,7-diones were successfully synthesized with moderate to good yields using a new synthetic approach. The structures of the regio-isomers in this series were determined by single crystal X-ray analysis and NMR spectra.