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ChemInform Abstract: Synthesis and Structure—Activity Relationships of 2-Pyridones. Part 2. 8-(Fluoro-Substituted Pyrrolidinyl)-2-pyridones as Antibacterial Agents.

✍ Scribed by Q. LI; ET AL. ET AL.

Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis and Structure-Activity Relationships of 2-Pyridones. Part 2. 8-(Fluoro-Substituted Pyrrolidinyl)-2-pyridones as Antibacterial Agents.

-Various 2-pyridones, e.g. (III) and (V), are prepared in a previously reported manner and are investigated for their antibacterial activity. It is shown that N-substitution at position C-8 is necessary for DNA-binding activity. Most potent compounds are (IIIa) and (V). The enantiomer of (V) is also active in the same range. Additionally the synthesis of the amine educts of type (II) and (IV) are reported. -(LI, Q.;

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