A series of 2'-benzamido-2'-deoxyadenosine analogues were synthesized in an effort to find new lead structures for the treatment of sleeping sickness. The 2'-deoxy-2'-(3-methoxybenzamido)adenosine (lh) was proved to be a selective inhibitor of the parasite glyceraldehyde 3-phosphate dehydrogenase wh
ChemInform Abstract: Synthesis and Structure-Activity Relationships of Analogues of 2′- Deoxy-2′-(3-methoxybenzamido)adenosine, a Selective Inhibitor of Trypanosomal Glycosomal Glyceraldehyde-3-phosphate Dehydrogenase ( GAPDH).
✍ Scribed by S. VAN CALENBERGH; C. L. M. J. VERLINDE; J. SOENENS; A. DE BRUYN; M. CALLENS; N. M. BLATON; O. M. PEETERS; J. ROZENSKI; W. G. J. HOL; P. HERDEWIJN
- Book ID
- 112025484
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 36 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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