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ChemInform Abstract: Synthesis and Quantitative Structure—Activity Relationship of a New Series of Chiral 4-Alkoxycarbonyl-2-(alkylamino)-1,3,2-oxa or thiazaphospholidine-2-ones.

✍ Scribed by Hussein M. Ali; Khaled A. Mohamed

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
30
Category
Article
ISSN
0931-7597

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Synthesis and quantitative structure–act
Synthesis and quantitative structure–activity relationship of a new series of chiral 4-alkoxycarbonyl-2-(alkylamino)-1,3,2-oxa or thiazaphospholidine-2-ones
✍ Hussein M. Ali; Khaled A. Mohamed 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB 👁 2 views

Twenty-one of the chiral 4-alkoxycarbonyl-2-(␣-alkyl-␣-ethoxycarbonyl methylamino)-1,3-2-thia or oxazaphospholidine-2-ones have been synthesized by cyclization of L-serine or L-cysteine ethyl or n-octyl ester with phosphoryl chloride followed by reaction with a suitable L-amino acid ethyl ester. Pro