ChemInform Abstract: Synthesis and Mutagenic Potency of Structural Isomers of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
โ Scribed by W. Chrisman; M. G. Knize; M. J. Tanga
- Publisher
- John Wiley and Sons
- Year
- 2009
- Weight
- 36 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0931-7597
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2-Amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5f]quinoline (IQ) are two important heterocyclic amines formed in proteinaceous foods during the cooking process. Both PhIP and IQ are carcinogenic in several strains of rats. PhIP induces mammary tumors in female F3
The base pair substitution mutational profiles in-position (CCCrCTC; 96-99% of total). Base substiduced by the heterocyclic amine cooked food muta-tution mutagenesis induced by heterocyclic amines gens PhIP and IQ in Salmonella typhimurium strains related to PhIP is generally SOS-dependent, requir-T