ChemInform Abstract: Synthesis and Microbiological Activity of Some Novel N-(2-Hydroxyl-5-Substitutedphenyl)benzacetamides, Phenoxyacetamides and Thiophenoxyacetamides as the Possible Metabolites of Antimicrobially Active Benzoxazoles.

✍ Scribed by I. YALCIN; B. K. KAYMAKCIOGLU; I. OEREN; E. SENER; OE. TEMIZ; A. AKIN; N. ALTANLAR

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199828100

✦ Synopsis

Synthesis and Microbiological Activity of Some Novel N-(2-Hydroxyl-5-Substitutedphenyl)benzacetamides, Phenoxyacetamides and Thiophenoxyacetamides as the Possible Metabolites of Antimicrobially Active Benzoxazoles.

-The novel compounds, such as (III), exhibit significant activity against the enterobacter Pseudomonas aureginosae compared with the control drugs. Derivative (IIIb) is active against the whole Gram-positive bacteria strains and the Gram-negative microorganism Klebsiella pneumoniae. The highest antifungal activity against C. albicans shows derivative (IIIe). Furthermore, the antimicrobial activities of acetamides (IIIb)-(IIIe) are also compared with their cyclic analogues. Most of the benzoxazole derivatives show higher activity than the compared acetamides. -(YALCIN,