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ChemInform Abstract: Synthesis and Insecticidal Activities of Novel Spin-Labeled Derivatives of Camptothecin.

✍ Scribed by Ying-Qian Liu; et al. et al.

Publisher: John Wiley and Sons
Year: 2012
Weight: 12 KB
Volume: 43
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201210215

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✦ Synopsis

Abstract

Intermediate (Ia) and eight spin‐labeled camptothecin derivatives like (Ib) are synthesized from camptothecin and evaluated for their insecticidal activity against the fifth‐instar larva B.longissima in vivo.

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## 3 Results The values (24 h) of dimethyl-and di-allyl-LD 50 thiosuünate were comparable, varying from 0.02 mg litre~1 against P. interpunctella to 0.25 mg litre~1 against C. maculatus, although those for thiosulünates were generally lower than those for disulüdes. In comparison, 24-h values for