## Abstract For Abstract see ChemInform Abstract in Full Text.
ChemInform Abstract: Synthesis and in vitro Antiproliferative Activity of New Substituted Benzo[3′,2′:5,6]thiopyrano[4,3-d]pyrimidines.
✍ Scribed by Anna Maria Marini; Federico Da Settimo; Silvia Salerno; Concettina La Motta; Francesca Simorini; Sabrina Taliani; Daniele Bertini; Ornella Gia; Lisa Dalla Via
- Publisher
- John Wiley and Sons
- Year
- 2008
- Weight
- 26 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Starting from substrates (I), the title skeleton (VI) is prepared via tricyclic precursors of type (II).
of title derivatives which are evaluated for antiproliferative activity against a large panel of human tumor-derived cell lines compounds (I) are the most potent analogues in the series, showing remarkable effects on human splenic B-lymphoblastoid cells (WIL-2NS) and human acute B-lymphoblastic leuk