Synthesis and highly diastereoselective
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Alan R. Katrizky; Saad R. El-Zemity; Peter Leeming; Chris M. Hartshorn; Peter J.
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Article
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1996
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Elsevier Science
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English
β 472 KB
Amino-3~5-bis(1-hydroxyethyl)-l,2,4-triazole 2 (SAT) (from (S)-lactic acid and hydrazine hydrate) reacted with substituted benzaldehydes 6 to afford N-[(S,S)-3,5-bis(1hydroxyethyl)-l,2,4-triazol-4-yl]arylimines 3 in excellent yield. Protection of the hydroxyl groups in compounds 3 was accomplished u