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ChemInform Abstract: Synthesis and Highly Diastereoselective Alkylation of Chiral N-((S,S)- 3,5-bis(1-methoxyethyl)-1,2,4-triazol-4-yl)arylimines.

✍ Scribed by A. R. KATRITZKY; S. R. EL-ZEMITY; P. LEEMING; C. M. HARTSHORN; P. J. STEEL


Book ID
112038920
Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis and highly diastereoselective
✍ Alan R. Katrizky; Saad R. El-Zemity; Peter Leeming; Chris M. Hartshorn; Peter J. πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 472 KB

Amino-3~5-bis(1-hydroxyethyl)-l,2,4-triazole 2 (SAT) (from (S)-lactic acid and hydrazine hydrate) reacted with substituted benzaldehydes 6 to afford N-[(S,S)-3,5-bis(1hydroxyethyl)-l,2,4-triazol-4-yl]arylimines 3 in excellent yield. Protection of the hydroxyl groups in compounds 3 was accomplished u