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ChemInform Abstract: Synthesis and Evaluation of Quinazolin-4-ones as Hypoxia-Inducible Factor-1α Inhibitors.

✍ Scribed by Wenwei Huang; Ruili Huang; Matias S. Attene-Ramos; Srilatha Sakamuru; Erika E. Englund; James Inglese; Christopher P. Austin; Menghang Xia

Publisher: John Wiley and Sons
Year: 2011
Weight: 22 KB
Volume: 43
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201201198

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✦ Synopsis

Abstract

Three areas of an initial quinazolinone‐based screening hit are modified for structure—activity relationship studies: the left part of the quinazolinone core, the piperazine region, and phenyl ring substitution.

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