Synthetic studies on duocarmycin. 2. Syn
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Yasumichi Fukuda; Kazuhiko Nakatani; Shiro Terashima
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Article
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1994
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Elsevier Science
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French
โ 922 KB
The title synthesis was achieved by featuring the optical resolution of two types of the tricyclic intermediates and the synthetic scheme established in the synthesis of racemic compounds. In vitro cytotoxicity assay against P388 murine leukemia obviously showed that the absolute configuration of cy