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ChemInform Abstract: Synthesis and Calcium Channel Modulating Effects of Isopropyl 1,4-Dihydro-2,6-dimethyl-3-nitro-4-(thienyl)-5-pyridinecarboxylates.

✍ Scribed by R. MIRI; S. E. HOWLETT; E. E. KNAUS

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199805136

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✦ Synopsis

Synthesis and Calcium Channel Modulating Effects of Isopropyl 1,4-Dihydro-2,6-dimethyl-3-nitro-4-(thienyl)-5-pyridinecarboxylates. -The synthesis of the title compounds (IV) (6 examples) by a modified Hantzsch reaction is reported. All the compounds exhibited only weak calcium channel antagonist activity. The most active derivative (IVb) is about 40-fold less potent than the reference drug nifedipine. -(MIRI, R.

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