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ChemInform Abstract: Synthesis and Biology of the Rigidified Glutamate Analogue, trans-2- Carboxyazetidine-3-acetic Acid (t-CAA).

✍ Scribed by A. P. KOZIKOWSKI; Y. LIAO; W. TUECKMANTEL; S. WANG; S. PSHENICHKIN; A. SURIN; C. THOMSEN; J. T. WROBLEWSKI

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis and Biology of the Rigidified Glutamate Analogue, trans-2-Carboxyazetidine-3-acetic Acid (t-CAA). -The chemical approaches to the azetidine (-)-(VIII) and its homologue ( -)-(XII) are also used for the preparation of the enantiomers (+)-( VIII) and (+)-(XII). (+)-(VIII) is an inhibitor of Na+-dependent glucose uptake and acts as a kainate receptor ligand. -(KOZIKOWSKI, A.

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