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ChemInform Abstract: Synthesis and Biological Evaluation of Monoindolyl and Indolocarbazolyl Oxazolones and Imidazolones.

✍ Scribed by E. RODRIGUES PEREIRA; M. PRUDHOMME; M. SANCELME; M. OLLIER; D. SEVERE; J. F. RIOU; H. CREVEL; J. P. SAVINEAU; D. FABBRO; T. MEYER

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

1997 indole derivatives, isoindole derivatives indole derivatives, isoindole derivatives R 0140

43 -130

Synthesis and Biological Evaluation of Monoindolyl and Indolocarbazolyl Oxazolones and Imidazolones.

-The compounds (III), (VII), (X)-(XV) structurally related to MDL 27032 (XVI) a strong protein kinase C inhibitor are synthesized and tested for their biological activity. In general, all the compounds tested show only low or no inhibiting effect on protein kinase A or C, the best results being obtained for compound (XI). The bulky bis-indolyl compounds (X), (XI), (XIV), and (XV), show some antiproliferative activity on carcinoma cells. -(RODRIGUES

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