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ChemInform Abstract: Synthesis and Biological Evaluation of 2,2-Disubstituted 2-Aminoethanols: Analogues of FTY720.

✍ Scribed by M. KIUCHI; K. ADACHI; T. KOHARA; K. TESHIMA; Y. MASUBUCHI; T. MISHINA; T. FUJITA

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis and Biological Evaluation of 2,2-Disubstituted 2-Aminoethanols: Analogues of FTY720.

-Some title compounds of type (VII) are investigated for their immunosuppressive activity. The size of the alkyl groups and the absolute configuration at the quaternary carbon are important for the immunosuppressive activity. Thus, (R)-(VIIa) is the most active derivative. -(KIUCHI, M.;

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