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ChemInform Abstract: Synthesis and Biological Activity of a Potent Renin Inhibitor of the Azapeptide Type.

✍ Scribed by J. GANTE; M. KRUG; G. LAUTERBACH; R. WEITZEL

Book ID
112021666
Publisher
John Wiley and Sons
Year
2010
Weight
26 KB
Volume
26
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES

Synthesis and Biological Activity of a P
Synthesis and Biological Activity of a Potent Renin Inhibitor of the Azapeptide Type
✍ Gante, Joachim ;Krug, Michael ;Lauterbach, GΓΌnter ;Weitzel, Reinhard πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 286 KB

## Abstract A highly potent renin inhibitor of the azapeptide type (2) is synthesized by starting from the hydrazine derivative 3. This peptide analogue inhibits renin in the same range (nanomolar) as its purely peptidic original 2a, but reveals much higher specificity for renin than 2a does.

Synthesis of a Renin Inhibitor of the Az
Synthesis of a Renin Inhibitor of the Azapeptide Type
✍ Gante, Joachim ;Kahlenberg, Harald πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 294 KB

In 1962 "azapeptides" were described for the first time'). In these peptide analogs the a-CH group of one or more amino acid residues of a peptide chain is replaced with nitrogen.