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ChemInform Abstract: Synthesis and Antitumor Activity of 4-Phenyl-1-arylsulfonylimidazolidinones.

✍ Scribed by S.-H. JUNG; ET AL. ET AL.

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis

and Antitumor Activity of 4-Phenyl-1arylsulfonylimidazolidinones.

-The novel title compounds (VII) and (VIII) display highly potent and broad cytotoxicities. The most potent derivative (VIII) exhibits much more potent cytotoxicities than doxorubicin and highly effective antitumor activities against murine and human xenograft tumor models. Thus, this compound is considered to be a valuable candidate for the development of new anticancer agents containing sulfonylurea pharma-

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v