ChemInform Abstract: Synthesis and Antimicrobial Activity of Some New Derivatives of 6,12-Dihydroindolo[2,1-b]quinazolin-6,12-dione.

✍ Scribed by G. GRANDOLINI; V. AMBROGI; L. PERIOLI; M. GIANNANGELI; L. JOVICEVIC; V. ROSSI

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 37 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199828188

✦ Synopsis

Synthesis and Antimicrobial Activity of Some New Derivatives of 6,12-Dihydroindolo[2,1-b]quinazolin-6,12-dione.

-The novel compounds, derivatives of tryptantrine (VIII), are prepared in order either to increase solubility and to study structure-activity relationship. All compounds are tested for antimicrobial activity. The introduction of a salifiable chain at the 2-position bears lack or decrease of the activity. In this group, only compound (IVa) retains activity against Bacillus subtilis. Compounds with the masked 12-carbonyl group [with exception of (XI)] are less active than (VIII), showing the importance of this oxygenated function. The latter is also confirmed by the decreased activity of the dihydro derivatives (VII). -(GRANDOLINI, G.;