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ChemInform Abstract: Synthesis and Antimicrobial Activity of 2-(2′-Arylidene-hydrazino-acetyl-amino)-4-phenyl-1,3-thiazoles and 2-[2′-{4′′-Substituted-aryl-3′′-chloro-2′′-oxo-azetidine}-acetyl-amino] -4-phenyl-1,3-thiazoles.

✍ Scribed by S. K. Sonwane; S. D. Srivastava; S. K. Srivastava

Publisher
John Wiley and Sons
Year
2008
Weight
21 KB
Volume
39
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

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## Abstract The synthesis of two diastereomers of the title compound involves the coupling of 5‐lithiated 2‐(1,1‐dimethoxyethyl)thiazole (VI) with a Weinreb amide (V) derived from gluconolacetone, followed by asymmetric reduction of the ketone functionality.