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ChemInform Abstract: Synthesis and Antihypertensive Activity of 4-(Diazabicyclo[4.1.0]heptenyloxy)benzopyran Derivatives and Their Analogues.

✍ Scribed by H. HORINO; T. MIMURA; K. KAGECHIKA; M. OHTA; H. KUBO; M. KITAGAWA

Publisher
John Wiley and Sons
Year
2010
Weight
40 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis and Antihypertensive Activity of 4-(Diazabicyclo[4.1.0]heptenyloxy)benzopyran Derivatives and Their Analogues.

-In order to get improved compounds and more information about the structure-activity relationships the title analogues such as (Β±)-(V), (Β±)-(VI), (Β±)-(VIII), (-)-(IX), and (-)-(X) are synthesized. The structures of (Β±)-(Va) and (Β±)-(VIa) are proven by X-ray analysis. A compound which has high potency and a long duration of action is substance (-)-(VIb) obtained from the racemate by HPLC-separation. -(HORINO, H.; MIMURA, T.;

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