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ChemInform Abstract: Synthesis and Antiaggregating Activity of 3-Aminopiperidine-2,6-dione and 3-Aminopyrrolidine-2,5-dione Derivatives.

✍ Scribed by A. A. KRYS'KO; V. M. KABANOV; T. A. KABANOVA; M. V. BELIKOVA; A. V. MAZEPA

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis and Antiaggregating Activity of 3-Aminopiperidine-2,6dione and 3-Aminopyrrolidine-2,5-dione Derivatives.

-Several substituted 3-aminopiperidine-2,6-diones as well as their pyrrolidine analogues [cf. (VI), (VIII)] are prepared via reaction of anhydrides derived from N-Boc-protected 2-aminoalkanedioic acids (III) with pyridylamines (IV). All the compounds obtained inhibit the aggregation of thrombocytes. It is shown that introduction of the N-pyridyl group into the piperidinediones or pyrrolidinediones generally increases the antiaggregating activity as compared to the parent compounds such as (II). -(KRYS'

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