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ChemInform Abstract: Synthesis and Analysis of Polyethylene Glycol Linked P-Glycoprotein-Specific Homodimers Based on (-)-Stipiamide.

โœ Scribed by Merritt B. Andrus; Timothy M. Turner; Emily P. Updegraff; Zuben E. Sauna; Suresh V. Ambudkar


Publisher
John Wiley and Sons
Year
2001
Weight
29 KB
Volume
32
Category
Article
ISSN
0931-7597

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Synthesis and analysis of polyethylene g
โœ Merritt B Andrus; Timothy M Turner; Emily P Updegraff; Zuben E Sauna; Suresh V A ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 77 KB

A series of five homodimeric polyethylene glycol (PEG) linked homodimers based on the multidrug resistance reversal agent (-)-stipiamide were made and tested for their ability to interact with P-glycoprotein, the protein responsible for multidrug resistance, using ATPase and photoaffinity displaceme