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ChemInform Abstract: Syntheses of β-Lactam Antibiotics via Ester Enolate-Imine Condensation Routes

✍ Scribed by M. PANUNZIO; P. G. COZZI; C. M. KRETZ; E. BANDINI; G. MARTELLI


Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
29
Category
Article
ISSN
0931-7597

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Theoretical study of ester enolate-imine
✍ Del R�o, E.; L�pez, R.; Men�ndez, M. I.; Sordo, T. L.; Ruiz-L�pez, M. F. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 356 KB

The condensation reaction of the enolate of methyl acetate with formaldimine to afford a ␤-lactam was studied using the MP2-FCr6-31qG\* level of theory taking into account the electrostatic effect of the solvent by means of a self-consistent reaction field continuum model. The reaction is a stepwise