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ChemInform Abstract: Syntheses of “Unstable” Diol Epoxide Metabolites of the Potent Carcinogens 7- and 12-Methylbenz(a)anthracene.

✍ Scribed by R. G. HARVEY; C. CORTEZ; A. KISELYOV

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

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7,12-Dimethylbenz[a]anthracene (DMBA), a potent carcinogen, requires metabolic activation by cytochrome P450s (P450s) t o electrophilic metabolites that result in DNA modification, mutagenicity, and carcinogenicity. In this study, we used eight human forms, four rodent forms, and one rabbit form of