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ChemInform Abstract: Syntheses of 2-((1S,3S)-1-Amino-3-carboxy-3-hydroxypropyl)thiazole-4- carboxylic Acid and the Tripeptide Skeleton of Nosiheptide Containing the Acid.

โœ Scribed by C. SHIN; Y. NAKAMURA; Y. YAMADA; Y. YONEZAWA; K. UMEMURA; J. YOSHIMURA


Book ID
112029101
Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
27
Category
Article
ISSN
0931-7597

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Conformationally restricted P1-P1' trans
โœ Michael J. Melnick; Sharon N. Bisaha; Ronald B. Gammill ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 256 KB

A concise synthesis and determination of absolute stereochemistry of two novel diastereomeric cyclopropyl containing transition state mimics isdescribed. A major advance in the development of renin inhibitors was the replacement of the scissile bond (PI-PI') with "transition state mimics" such as st