ChemInform Abstract: Susceptibility of Morpholine Substituents to Photo-Oxidative Decomposition — Identification of Photo-Oxidative Degradants of Linezolid (PNU-100766).

Susceptibility of morpholine substituent

Susceptibility of morpholine substituents to photo-oxidative decomposition-identification of photo-oxidative degradants of linezolid (PNU-100766)

✍ Gary E. Martin; Russell H. Robins; Phil B. Bowman; Wayne K. Duholke; Kathleen A. 📂 Article 📅 1999 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 507 KB

Parenteral formulations of linezolid (PNU-100766), a novel ( \(S\) )-3-(4'-fluorophenyl)-5- \(N\)-acetamidomethyloxazolidin-2-one antibiotic, were subjected to photo-stability testing as required by ICH guidelines. Direct, reversed phase chromatographic evaluation of the photo-irradiated solutions r