✦ LIBER ✦
ChemInform Abstract: Studies on Organosilicon Chemistry. Part 139. Uncatalyzed Aldol Reaction Using a Dimethylsilyl Enolate and α-Dimethylsilyl Ester in N,N-Dimethylformamide.
✍ Scribed by K. MIURA; H. SATO; K. TAMAKI; H. ITO; A. HOSOMI
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 39 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Studies on Organosilicon Chemistry. Part 139. Uncatalyzed Aldol Reaction Using a Dimethylsilyl Enolate and α-Dimethylsilyl Ester in N,N-Dimethylformamide.
-Dimethylsilyl enolates react with aldehydes in DMF to give the expected aldol adducts with almost no or little diastereoselectivity. α-Dimethylsilyl esters react in a similar manner to β-hydroxy esters. The introduction of hydrogen to the silicon enhances the reactivity of the enolates or esters compared to the corresponding trimethylsilyl derivatives. -(MIURA, K.;