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ChemInform Abstract: Studies on Nonpeptide Angiotensin II Receptor Antagonists. Part 1. Synthesis and Biological Evaluation of Pyrazolo[1,5-b][1,2,4]triazole Derivatives with Alkyl Substituents.

✍ Scribed by T. OKAZAKI; A. SUGA; T. WATANABE; K. KIKUCHI; H. KURIHARA; M. SHIBASAKI; A. FUJIMORI; O. INAGAKI; I. YANAGISAWA

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199828312

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✦ Synopsis

Studies on Nonpeptide Angiotensin II Receptor Antagonists. Part 1. Synthesis and Biological Evaluation of Pyrazolo[1,5-b][1,2,4]triazole Derivatives with Alkyl Substituents.

-In order to find a novel series of orally active non-peptide AII antagonists various kinds of the title derivatives such as (I) are synthesized. Among all compounds the potassium salt of (Id), named YM 358, is selected for further evaluation in vitro and in vivo. The structure of (Id) is determined by X-ray analysis. -(OKAZAKI, T.; SUGA,

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