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ChemInform Abstract: Structure—Reactivity Relationships of L-Proline Derived Spirolactams and α-Methyl Prolinamide Organocatalysts in the Asymmetric Michael Addition Reaction of Aldehydes to Nitroolefins.

✍ Scribed by Fintan Kelleher; Sinead Kelly; John Watts; Vickie McKee


Publisher
John Wiley and Sons
Year
2010
Weight
26 KB
Volume
41
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

Among a range of L‐proline‐derived lactams and amides, spirocyclic lactams (I), (II) and amide (III) possess the best catalytic activity in the title Michael addition of aldehydes towards β‐nitrostyrenes (IV).