✍ Scribed by M. LEHR
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Structure-Activity Relationships of (4-Acylpyrrol-2-yl)alkanoic Acids as Inhibitors of the Cytosolic Phospholipase A 2 : Variation of the Substituents in Positions 1, 3, and5. -Investigation of the structureactivity relationship of lead compounds (I) by variation of the substituents in position 1, 3, and 5 and of the length of the acyl chain in position 4 leads to a series of compounds, e.g. (II), (III), and (IV), among which compounds (IVc) and (IVd) are in vitro inhibitors of platelet cytosolic phospholipase A 2 with the greatest potency. -(LEHR, M.;
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1997 indole derivatives, isoindole derivatives indole derivatives, isoindole derivatives R 0140 ## 49 -143 Synthesis, Biological Evaluation, and Structure-Activity Relationships of 3-Acylindole-2-carboxylic Acids as Inhibitors of the Cytosolic Phospholipase A2. -All title compounds are synthesize