ChemInform Abstract: Structure—Activity Relationship for a Series of 2-Substituted 1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indoles: Potent Subtype-Selective Inhibitors of N-Methyl-D-aspartate (NMDA) Receptors.

✍ Scribed by Amir P. Tamiz; Edward R. Whittemore; Richard M. Woodward; Ravindra B. Upasani; John F. W. Keana

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199937155

✦ Synopsis

Structure-Activity Relationship for a Series of 2-Substituted 1,2,3,4-Tetrahydro-9H-pyrido [3,4-b]indoles: Potent Subtype-Selective Inhibitors of N-Methyl-D-aspartate (NMDA) Receptors.

-In continuation of an earlier work a series of pyridoindole-based compounds such as (III) and (VI) are synthesized. The structure-activity relationships are discussed. Among all substances (VI) is the most potent antagonist (IC 50 = 50nM). -(TAMIZ, AMIR P.;