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ChemInform Abstract: Structure, Physiological Role, and Specific Inhibitors of Human Thymidine Kinase 2 (TK2): Present and Future

✍ Scribed by Maria-Jesus Perez-Perez; Eva-Maria Priego; Ana-Isabel Harnandez; Olga Familiar; Maria-Jose Camarasa; Ana Negri; Federico Gago; Jan Balzarini

Publisher: John Wiley and Sons
Year: 2008
Weight: 15 KB
Volume: 39
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200847265

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## Abstract Human mitochondrial thymidine kinase (TK2) is a pyrimidine deoxynucleoside kinase (dNK) that catalyzes the phosphorylation of pyrimidine deoxynucleosides to their corresponding deoxynucleoside 5′‐monophosphates by γ‐phosphoryl transfer from ATP. In resting cells, TK2 is suggested to pla

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