ChemInform Abstract: Structure-Odor Relationships
✍ Scribed by K. J. ROSSITER
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 23 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The seven spirocyclic ethers **4**–**10**, related to the tricyclic odorant __Ambrox__ ^®^ (**1**) and its diastereoisomers **2** and **3**, were synthesized. Their odoriferous activity/inactivity was correlated with the steric accessibility of the ether O‐atom, calculated by computer‐a
## Abstract By means of a convergent synthesis strategy, the title substance (__Z__)‐7‐oxa‐β‐santalol (4) was prepared starting with the side chain synthon 5‐iodo‐2‐methyl‐2‐pentenylmethoxyethoxymethyl ether (7) and the bicyclic synthon ethyl 3‐methylene‐7‐oxabicyclo[2.2.1]hept‐5‐ene‐2‐carboxylate