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ChemInform Abstract: Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide- Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non- Peptidic Inhibitors.

โœ Scribed by S. THAISRIVONGS; M. N. JANAKIRAMAN; K.-T. CHONG; P. K. TOMICH; L. A. DOLAK; S. R. TURNER; J. W. STROHBACH; J. C. LYNN; M.-M. HORNG; R. R. HINSHAW; K. D. WATENPAUGH


Book ID
112037660
Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
27
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Design and Synthesi
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Design and Synthesis of Novel 2,7-Dialkyl Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro Potent Peptidomimetic Inhibitors of Human Renin. -Novel renin inhibitors (I), which are created on a topographical design approach, are prepared by literature methods. (I) have IC 50