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ChemInform Abstract: Structural Determinants of Substrates and Inhibitors: Probing Glutamate Transporters with 2,4-Methanopyrrolidine-2,4-dicarboxylate.

✍ Scribed by C. Sean Esslinger; Hans P. Koch; Michael P. Kavanaugh; Dean P. Philips; A. Richard Chamberlin; Charles M. Thompson; Richard J. Bridges

Book ID: 101873626
Publisher: John Wiley and Sons
Year: 2010
Weight: 29 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199911225

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✦ Synopsis

Structural Determinants of Substrates and Inhibitors: Probing Glutamate Transporters with 2,4-Methanopyrrolidine-2,4-dicarboxylate. -The title compound (VII), a conformationally locked analogue of glutamate, is prepared via intramolecular [2 + 2] photocyclization of intermediate (VI) and used for binding studies to sodium-dependent excitatory amino acid transporters. -(ESSLINGER, C.

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