## Synthesis of Ξ±-Amino Phosphonates under Diastereocontrol by Imidazolidin-2-one Auxiliaries. -Ephedrine-derived chiral auxiliaries, cf. compound (I), are easily prepared and show high stability and crystallinity.
ChemInform Abstract: Stereoselective Synthesis via Imidazolidin-2-one Auxiliaries
β Scribed by Gregory Roos
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 24 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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In the presence of titanium(IV) tetraethoxide ((EtO) 4 Ti), menthyl arylglyoxylates are prepared by transesterification of ethyl arylglyoxylates and natural (Γ)-(1R,2S,5R)-menthol. Using menthyl as a chiral auxiliary, the corresponding novel (R)-menthyl 2-aryl-2-hydroxybutanoates are synthesized by