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ChemInform Abstract: Stereoselective Synthesis of Freidinger Lactams Using Oxaziridines Derived from Amino Acids.

✍ Scribed by M. S. WOLFE; D. DUTTA; J. AUBE


Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis


Stereoselective Synthesis of Freidinger Lactams Using Oxaziridines Derived from Amino Acids.

-Enantiopure Freidinger lactams, e.g. (IV), (VII), and (X), are synthesized via the corresponding oxaziridines. Although the preparation of the chiral spirocyclic oxaziridines often leads to more than one diastereomer, separation is not necessary in some cases, since the mixtures converge upon the same lactam. The utility of this method is illustrated by the synthesis of potential inhibitors of angiotensin-converting enzyme. -(WOLFE, M.


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