ChemInform Abstract: Stereoselective Synthesis of Enantiopure Cyclic α-Aminophosphonic Acids: Direct Observation of Inversion at Phosphorus in Phosphonate Ester Silyldealkylation by Bromotrimethylsilane.

Stereoselective synthesis of enantiopure

Stereoselective synthesis of enantiopure cyclic α-aminophosphonic acids: Direct observation of inversion at phosphorus in phosphonate ester silyldealkylation by bromotrimethylsilane

✍ Vladimir A. Alfonsov; Charles E. McKenna; Evgenia V. Bayandina; Boris A. Kashemi 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 179 KB

## Abstract The paper describes a simple, direct synthesis of enantiopure cyclic α‐aminophosphonic acids on the basis of silyldealkylation and followed by hydrolysis of the parent diastereoisomeric cyclic 1,4,2‐oxazaphosphorines, which have been obtained by intramolecular stereospecific nucleophili