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ChemInform Abstract: Stereoselective Synthesis of (+)-CP-99,994: A Substance P Non-Peptide Antagonist.

✍ Scribed by S. Chandrasekhar; Pradyumna K. Mohanty


Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
30
Category
Article
ISSN
0931-7597

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## Abstract Opioids and the neuropeptide substance P (SP) modulate the expression of inflammatory cytokines and chemokines, which are under the control of nuclear factor ΞΊB (NF‐κB). We investigated whether the neurokinin‐1 receptor (SP receptor) pathway is biologically involved in morphine‐mediated