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ChemInform Abstract: Stereoselective Preparation of Syn α-Hydroxy-β-amino Ester Units via Regioselective Opening of α,β-Epoxy Esters: Enantioselective Synthesis of Taxol C-13 Side Chain and Cyclohexylnorstatine.

✍ Scribed by G. RIGHI; G. RUMBOLDT; C. BONINI


Book ID
112037215
Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
27
Category
Article
ISSN
0931-7597

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Practical preparation of α-hydroxy-β-ami
✍ Kouji Hattori; Hisashi Yamamoto 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 509 KB

An asymmetric reaction of chiral imines with a-silyloxy ketene acetals mediated by chiral boron reagents is described. The key to its success is the use of the chiral boron complex prepared in situ from (R)or (S')binaphthol and B(OPh)g. Both diastereomers of a-hydroxy-P-amino ester units are success