Practical preparation of α-hydroxy-β-ami
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Kouji Hattori; Hisashi Yamamoto
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Article
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1994
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Elsevier Science
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French
⚖ 509 KB
An asymmetric reaction of chiral imines with a-silyloxy ketene acetals mediated by chiral boron reagents is described. The key to its success is the use of the chiral boron complex prepared in situ from (R)or (S')binaphthol and B(OPh)g. Both diastereomers of a-hydroxy-P-amino ester units are success