ChemInform Abstract: Stereoselective Conversion of 2′,3′-Dideoxydidehydro Carbocyclic Nucleosides into 2′-Deoxy Carbocyclic Nucleosides.

✍ Scribed by J. V. BARKLEY; A. DHANDA; L. J. S. KNUTSEN; M.-B. NIELSEN; S. M. ROBERTS; D. R. VARLEY

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199838259

✦ Synopsis

Stereoselective Conversion of 2',3'-Dideoxydidehydro Carbocyclic Nucleosides into 2'-Deoxy Carbocyclic Nucleosides.

-A novel transformation of known alkenes such as (I) to the 2'-deoxy derivatives such as (V) and (VI) is presented. It is noteworthy that the use of N-bromoacetamide instead of NBS as reagent is possible. The stereochemistry of compound (IVa) is confirmed by X-ray analysis. -(BARKLEY,