✦ LIBER ✦
ChemInform Abstract: Stereoselective Conjugate Addition Directed by an Enantiomerically Pure Ketal. Preparation of the Cyclohexanone Fragment of N-Methylwelwitindolinone C Isothiocyanate.
✍ Scribed by J. P. KONOPELSKI; H. DENG; K. SCHIEMANN; J. M. KEANE; M. M. OLMSTEAD
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Stereoselective Conjugate Addition Directed by an Enantiomerically Pure Ketal. Preparation of the Cyclohexanone Fragment of N-Methylwelwitindolinone C Isothiocyanate.
-A cyclohexanone intermediate (V), which may be employed in the synthesis of the marine natural product N-methylwelwitindolinone C isothiocyanate, is prepared based on a diastereoselective conjugate addition of Grignard reagent (II) to the α,β-unsaturated ketone (I) bearing an adjacent chiral ketal as directing group.
-(KONOPELSKI,