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ChemInform Abstract: Stereoselective Azepine-Ring Formation Through Ene Reactions of 3-(Alk-2-enyl)amino-2-cyanoacrolein Derivatives.

✍ Scribed by Michihiko Noguchi; Hisashi Yamada; Shinji Takamura; Takehiko Uchida; Mitsuko Hironaka; Akikazu Kakehi; Hidetoshi Yamamoto


Publisher
John Wiley and Sons
Year
2001
Weight
34 KB
Volume
32
Category
Article
ISSN
0931-7597

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Stereoselective Azepine-Ring Formation T
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Ene reactions / Azepines / 3-(Alk-2-enyl)aminoacroleins The reaction of 3-[N-(alk-2-enyl)benzylamino]-2-cyanoacroleins 9 with primary amines 12 and 13 gave 4,5-dihydro-1Hazepines 14 and 15 stereoselectively, through an intramolecular ene reaction of the imine derivatives of 9. Similarly, carbonyl-e

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