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ChemInform Abstract: Stereoelectronic Substituent Effects in Polyhydroxylated Piperidines and Hexahydropyridazines.

✍ Scribed by Henrik Helligsoe Jensen; Laila Lyngbye; Astrid Jensen; Mikael Bols

Publisher
John Wiley and Sons
Year
2010
Weight
23 KB
Volume
33
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES

Stereoelectronic Substituent Effects in
Stereoelectronic Substituent Effects in Polyhydroxylated Piperidines and Hexahydropyridazines
✍ Henrik HelligsΓΈ Jensen; Laila Lyngbye; Astrid Jensen; Mikael Bols πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 178 KB

From the pK a values of the conjugate acids of a large series of hydroxylated piperidines and hexahydropyridazines, a consistent difference in basicity was found between stereoisomers having an axial or equatorial hydroxyl (OH) group either b or g to the amine. Compounds with an equatorial OH group