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ChemInform Abstract: Stereochemistry of Chiral Sulfoxides Used for the Synthesis of Antitumor Antibiotic Analogues of Sparsomycin.

✍ Scribed by A. HEMPEL; N. CAMERMAN; J. GRIERSON; D. MASTROPAOLO; A. CAMERMAN


Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
28
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Asymmetric Synthesi
✍ W. OPPOLZER; O. FROELICH; C. WIAUX-ZAMAR; G. BERNARDINELLI πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 33 KB πŸ‘ 2 views

The diastereomerically pure sulfinylating reagent (III) reacts with nucleophilic Grignard reagents or the zinc reagent derived from (VI) to yield chiral sulfoxides with excellent yields and enantioselectivities. Under specific conditions sequential reaction of (III) with LiN(Tms)2 followed by aldehy