ChemInform Abstract: Stereochemical Variations on the Colchicine Motif. Part 3.The First Colchicine Analogues with an Eight-Membered B-Ring. Structure, Optical Resolution and Inhibition of Microtubule Assembly.

✍ Scribed by U. BERG; H. BLADH; C. SVENSSON; M. WALLIN

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 29 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199810179

✦ Synopsis

Stereochemical Variations on the Colchicine Motif. Part 3.The First Colchicine Analogues with an Eight-Membered B-Ring. Structure, Optical Resolution and Inhibition of Microtubule Assembly. -The desired title compound is prepared and investigated by X-ray crystal analysis. The enantiomeric resolution show that only (-)-(II) can inhibit microtubule assembly. -(BERG, U.;